PHRM 233

Fri, 15 Dec 2006 20:41:18 GMT

1. Consider 1 mg of a drug with MW = 200
0.001g /(200 g/mol) x (6.02 x 10^23) = 3 x 10^18 molecules administered
The human body has about 3 x 10^13 cells.
3 x 10^18 molecules ÷ (3 x 10^13 cells) = 10^5 molecules acting on each cell.
One erythrocyte cell contains 10^10 molecules.
Assuming the same number of molecules on each cell.
then
10^10 (molecules per cell) ÷ 10^5 (total drug molecules) =
10^5 molecules in the body per single drug molecule administered

2. Equilibrium depends on
•Concentration (of molecules involved)
•Stoichiometry (of the reaction)
•Affinity (between molecules)
Energy associated with these interactions derives from and is
determined by, the number and types of forces that are involved
in the transition.

3. Doxorubicin is one of the most widely used
anthracyclines in cancer therapy
• Side effects: cardiotoxicity and drug
resistance
• Synthesis of analogs of daunomycin
• One analog shows less cytotoxicity but is
active against doxorubicin-resistant cells

4. Anthracyclines

Intercalate between two base pairs in DNA, distorting helix and preventing
topoisomerase II activity. Amino sugar lies in minor groove and prevents
topoisomerase I activity. Daunomycin most effective in leukemia

Si je sais...: PHARMACY

PHRM 233